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DeCS
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Descriptor English:
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Mutagenesis, Insertional
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Descriptor Spanish:
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Mutagénesis Insercional
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Descriptor Portuguese:
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Mutagênese Insercional
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Synonyms English:
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Gene Insertion
Insertion Mutation
Insertional Activation
Insertional Mutagenesis
Linker-Insertion Mutagenesis
Mutagenesis, Cassette
Sequence Insertion
Viral Insertional Mutagenesis
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Tree Number:
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E05.393.420.601.550
G05.600.550
G13.920.590.575
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Definition English:
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Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation. |
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See Related English:
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DNA Transposable Elements
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History Note English:
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91
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Allowable Qualifiers English:
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Record Number:
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29057
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Unique Identifier:
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D016254
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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